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etoposide + mitomycin C + vindesine
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous
01
Overview
The combination of etoposide, mitomycin C, and vindesine—commonly referred to as the MEV regimen—is a chemotherapeutic protocol used primarily in the treatment of advanced or metastatic non-small-cell lung cancer (NSCLC). Etoposide is a topoisomerase II inhibitor that induces DNA strand breaks and inhibits DNA synthesis. Mitomycin C is an alkylating agent that crosslinks DNA, leading to inhibition of DNA replication and cell death. Vindesine is a vinca alkaloid that disrupts microtubule formation, thereby inhibiting mitosis. The MEV regimen has demonstrated activity in NSCLC with moderate response rates and manageable toxicity profiles[1][2].
- Other names
- MEV regimen
02
Targets
TUBB (Tubulin (alpha and beta subunits))DNATOP2A (DNA topoisomerase II)
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