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etoricoxib + betamethasone
- Development stage
- Preclinical
- Lead developer
- Laboratorios Silanes S.A. de C.V.
- Modality
- Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
Etoricoxib + betamethasone is an oral fixed-dose combination drug under development for the treatment of inflammatory and painful conditions, particularly those associated with arthritis. Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that reduces inflammation and pain by inhibiting prostaglandin synthesis from arachidonic acid. Betamethasone is a long-acting synthetic corticosteroid with potent anti-inflammatory and immunosuppressive properties, acting primarily as a glucocorticoid receptor agonist to suppress multiple inflammatory pathways. The combination aims to provide enhanced anti-inflammatory effects through dual mechanisms: COX-2 inhibition and glucocorticoid receptor activation[1][2][3][4].
- Other names
- etoricoxib/betamethasone
02
Targets
GR (Glucocorticoid receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)
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