Drug intelligence / Profile preview

etoricoxib + diacerein

Development stage
Unknown
Lead developer
Liomont
Modality
Small Molecules
Administration
Oral
01

Overview

etoricoxib + diacerein is a fixed-dose combination therapy developed by Laboratorios Liomont for the treatment of pain associated with osteoarthritis, specifically targeting knee and hip joints. Etoricoxib is a selective cyclooxygenase-2 (COX-2) inhibitor that provides rapid analgesic and anti-inflammatory effects by reducing prostaglandin synthesis. Diacerein is an anthraquinone derivative that acts as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) by inhibiting interleukin-1 beta (IL-1β), a key pro-inflammatory cytokine involved in cartilage degradation and joint inflammation. This combination aims to provide both immediate symptomatic relief and potential long-term disease-modifying benefits in patients with osteoarthritis.

Brand names
Artrocox D
Other names
diacerein + etoricoxib
02

Targets

PTGS2 (Prostaglandin-Endoperoxide Synthase 2)PGHS-1 (Prostaglandin G/H Synthase 1)ALOX12 (Arachidonate 12-lipoxygenase, 12S type)CYP3A (CYP3A family)LXRB (Liver X receptor beta)NR1H3 (Liver X receptor beta)NAT (Arylamine N-acetyltransferase 2)

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