Drug intelligence / Profile preview

etoricoxib + paracetamol

Development stage
Unknown
Lead developer
Solis Pharma
Modality
Small Molecules
Administration
Oral
01

Overview

Etoril P is a fixed-dose combination analgesic developed and marketed by Solis Pharms for pain management. It contains **etoricoxib**, a selective cyclooxygenase-2 (COX-2) inhibitor, and **paracetamol** (acetaminophen), a non-opioid analgesic and antipyretic. Etoricoxib provides anti-inflammatory and analgesic effects by specifically inhibiting the COX-2 enzyme, which is responsible for prostaglandin synthesis at sites of inflammation, while sparing the COX-1 enzyme associated with gastrointestinal protection. Paracetamol complements this by providing additional pain relief and fever reduction, likely through central nervous system mechanisms. The combination is typically indicated for the symptomatic relief of acute pain, osteoarthritis, rheumatoid arthritis, and other musculoskeletal conditions where both anti-inflammatory and analgesic actions are required.

Brand names
Etoril P
Other names
etoricoxib + acetaminophen
02

Targets

PGHS-1 (Prostaglandin G/H Synthase 1)COX POX site (Prostaglandin-endoperoxide synthase 1 (COX-1) peroxidase site)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)

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