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EV71 vaccine (NHRI)
- Development stage
- Unknown
- Lead developer
- Medigen Vaccine Biologics
- Modality
- Whole Inactivated Vaccines → Inactivated Vaccines → Prophylactic Vaccines → Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
The EV71 vaccine developed by the National Health Research Institutes (NHRI) of Taiwan is a monovalent, formalin-inactivated whole-virus vaccine candidate produced using Vero cell culture technology. Formulated with an aluminum phosphate (AlPO4) adjuvant, it is designed to prevent Enterovirus 71 (EV71) infection, a primary cause of hand, foot, and mouth disease (HFMD) that can lead to severe neurological complications. Phase I clinical trials demonstrated that the vaccine is safe and immunogenic, eliciting cross-neutralizing antibodies against multiple EV71 subgenotypes, including B1, B4, B5, and C4A. The technology was developed by the Vaccine Research & Development Center at NHRI and has served as the basis for further clinical development by commercial partners in Taiwan.
- Other names
- NHRI Enterovirus 71 vaccineEnterovirus 71 vaccine (NHRI)
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