Drug intelligence / Profile preview

Exone-A (HK inno.N Corporation)

Development stage
Unknown
Lead developer
HK inno.N Corporation
Modality
Small Molecules
Administration
Oral
01

Overview

**Exone-A** is an oral fixed-dose combination small-molecule tablet developed by **HK inno.N** for patients with **hypertension and dyslipidemia**. Public sources identify it as a three-drug combination containing **amlodipine**, **valsartan**, and **atorvastatin**, corresponding to the sponsor development code **CJ-30061** in a clinical pharmacokinetic study. Its therapeutic rationale is complementary cardiovascular risk control: amlodipine blocks L-type calcium channels to reduce vascular smooth-muscle tone, valsartan antagonizes the angiotensin II type 1 receptor to inhibit the renin-angiotensin system and lower blood pressure, and atorvastatin inhibits HMG-CoA reductase to reduce hepatic cholesterol synthesis and improve lipid parameters. HK inno.N lists Exone-A in its pipeline/product materials for hypertension with dyslipidemia and indicates an NDA/BLA-stage commercial program.

Brand names
Exone-A
Other names
amlodipine + valsartan + atorvastatin
02

Targets

CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)AGTR1 (Angiotensin II Type-1 receptor)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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