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ExPEC9V + HD quadrivalent influenza vaccine
- Development stage
- Unknown
- Lead developer
- Janssen Research & Development
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intramuscular
01
Overview
ExPEC9V + HD quadrivalent influenza vaccine is an investigational combination vaccine being developed by Janssen Vaccines & Prevention (a subsidiary of Johnson & Johnson). The combination consists of **ExPEC9V** (also known as VAC52416 or JNJ-78901563), a 9-valent bioconjugate vaccine targeting extraintestinal pathogenic *Escherichia coli* (ExPEC), and a high-dose (HD) quadrivalent seasonal influenza vaccine. ExPEC9V is designed to prevent invasive ExPEC disease (IED), including bloodstream infections and urosepsis, by targeting nine specific E. coli O-serotypes (O1, O2, O4, O6, O15, O16, O18, O25, and O75). The high-dose quadrivalent influenza component provides protection against four seasonal influenza virus strains. The combination is currently in Phase 3 clinical development, specifically being evaluated in adults aged 65 years and older to assess the safety and immunogenicity of co-administration compared to separate administration of the two vaccines.
- Other names
- ExPEC9V + high-dose quadrivalent influenza vaccineVAC52416 + HD quadrivalent influenza vaccine
02
Targets
HA (Hemagglutinin)
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