Drug intelligence / Profile preview

ezetimibe + fenofibrate (Hyundai Pharmaceutical Co., Ltd.)

Development stage
Unknown
Lead developer
Hyundai Pharmaceutical
Modality
Small Molecules
Administration
Oral
01

Overview

HDDO-17561/HDDO-17562 refers to the loose combination of ezetimibe and fenofibrate, developed by Hyundai Pharmaceutical for the treatment of hyperlipidemia. Ezetimibe is a selective cholesterol absorption inhibitor that acts at the brush border of the small intestine, while fenofibrate is a fibric acid derivative that activates peroxisome proliferator-activated receptor alpha (PPARα) to modulate lipid metabolism. This combination is typically used to lower LDL cholesterol and triglycerides while increasing HDL cholesterol. Hyundai Pharmaceutical conducted Phase 1 trials to compare the pharmacokinetics and safety of this loose combination against their fixed-dose combination (FDC) formulation, HDDO-1756.

Other names
ezetimibe + fenofibrate
02

Targets

NPC1L1 (Niemann-pick C1-Like 1 transporter)PPARA (Peroxisome proliferator-activated receptor alpha)

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