ezetimibe + simvastatin + niacin

Ezetimibe + simvastatin + niacin is a combination therapy used to treat high cholesterol and triglyceride levels in the blood, particularly in patients with hypercholesterolemia or at risk of cardiovascular disease. Ezetimibe acts as a dietary cholesterol absorption inhibitor, reducing the amount of cholesterol absorbed from the intestine. Simvastatin is an HMG-CoA reductase inhibitor (statin) that decreases endogenous cholesterol synthesis by inhibiting the rate-limiting enzyme in hepatic cholesterol production. Niacin (vitamin B3) lowers LDL-cholesterol and triglycerides while raising HDL-cholesterol by inhibiting hepatic diacylglycerol acyltransferase-2, decreasing VLDL synthesis, and reducing lipolysis in adipose tissue. This triple combination targets multiple pathways involved in lipid metabolism for comprehensive lipid control[1][2][4][5][8].