F-PEG-HAuNS + siRNA

**F-PEG-HAuNS + siRNA** is a combination drug comprised of folic acid-polyethylene glycol-hollow gold nanoshells (F-PEG-HAuNS) conjugated to small interfering RNA (siRNA)[7]. This nanoparticle-based delivery system is designed to target tumors expressing folic acid receptor, enhancing specific uptake by cancer cells via ligand-receptor interactions. The hollow gold nanoshell is coated with PEG for increased stability and circulation time, and functionalized with folic acid for receptor-mediated endocytosis. siRNA is covalently attached to the gold surface via the passenger strand[7], enabling delivery of gene-silencing RNA directly to tumor cells. Once internalized, siRNA is released to induce RNA interference, which results in the degradation of complementary mRNA and subsequent gene knockdown[5][6]. The primary mechanism is targeted gene silencing within folic acid receptor-positive tumor cells, making it a candidate for cancer therapeutics and proof-of-concept studies in gene therapy applications[7].

Other names

F-PEG-HAuNS-siRNAfolic acid-PEG-hollow gold nanoshell + siRNAF-PEG-HAuNS-siRNA nanoparticle