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factor viii (Baxter International Inc.)
- Development stage
- Unknown
- Lead developer
- Takeda
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
Factor VIII is an endogenous coagulation cofactor and a therapeutic replacement-protein class used to treat **hemophilia A** due to congenital factor VIII deficiency. Therapeutic factor VIII products may be plasma-derived or recombinant and include full-length, B-domain-deleted, single-chain, PEGylated, and Fc-fusion variants; therefore, the unqualified term does not identify one specific marketed product. Following activation to factor VIIIa, it serves as the essential cofactor for factor IXa in the intrinsic tenase complex, accelerating factor X activation and restoring thrombin generation and clot formation. ([medlineplus.gov](https://medlineplus.gov/download/genetics/gene/f8.pdf))
- Other names
- antihemophilic factorblood coagulation factor VIIIcoagulation factor VIIIfactor VIII:CFVIII
02
Targets
Coagulation Factor IXa
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