Drug intelligence / Profile preview

faldaprevir + raltegravir

Development stage
Unknown
Lead developer
Boehringer Ingelheim
Modality
Small Molecules
Administration
Oral
01

Overview

Faldaprevir + raltegravir is a combination of two small molecule antivirals used together in clinical contexts, primarily in the management of patients coinfected with hepatitis C virus (HCV) and human immunodeficiency virus (HIV). Faldaprevir is a potent inhibitor of the HCV NS3/4A protease and also inhibits UDP-glucuronosyltransferase 1A1 (UGT1A1), which can impact the pharmacokinetics of other drugs. Raltegravir is an HIV-1 integrase strand transfer inhibitor used as part of antiretroviral therapy. The combination has primarily been studied for drug-drug interactions and safety in co-infected patients.

Other names
faldaprevir + raltegravir
02

Targets

UGT1A1 (UDP-glucuronosyltransferase 1A1)NS3/4A (Hepatitis C virus nonstructural protein 3/4A serine protease)Integrase allosteric pocket (HIV)

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