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Fe0@HMON@DNA-Exo
- Development stage
- Preclinical
- Lead developer
- Dongguan People’s Hospital
- Modality
- Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
- Administration
- Intravenous, Intratumoral
01
Overview
**Fe0@HMON@DNA-Exo** is a research-stage, biologically logic-gated nano-Trojan-horse platform developed for **triple-negative breast cancer**. It consists of elemental iron synthesized within glutathione-responsive degradable hollow mesoporous organosilica nanoparticles and cloaked with DNA-fragment-containing exosomes derived from SN38-treated 4T1 breast cancer cells. In the high-glutathione, mildly acidic tumor microenvironment, iron release promotes Fenton-reaction reactive oxygen species generation and selective ferroptotic tumor-cell death. The DNA-containing exosomal shell also stimulates cGAS-STING signaling in antigen-presenting cells, promoting innate antitumor immunity. The platform has been reported in preclinical murine TNBC models and is not the same asset as Gate2Brain's G2B-002.
- Other names
- Fe⁰@HMON@DNA-Exo
02
Targets
LIP/PUFA (Tumor cell lipids and redox-active iron pool)Cyclic GMP–AMP synthaseSTING (Stimulator of interferon genes protein)
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