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fec + docetaxel + pertuzumab
- Development stage
- Unknown
- Lead developer
- Genentech
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
FEC-T plus pertuzumab is a multi-agent chemotherapy and targeted therapy regimen used primarily for the treatment of HER2-positive breast cancer. The FEC-T component consists of three chemotherapeutic agents—5-fluorouracil (F), epirubicin (E), and cyclophosphamide (C)—followed by docetaxel (T). Pertuzumab is a humanized monoclonal antibody that targets the extracellular dimerization domain of the human epidermal growth factor receptor 2 protein (HER2), blocking ligand-dependent heterodimerization with other HER family members and inhibiting downstream signaling pathways such as MAP kinase and PI3K. This results in cell growth arrest and apoptosis. Pertuzumab also mediates antibody-dependent cell-mediated cytotoxicity. The combination is indicated for neoadjuvant or adjuvant treatment in patients with HER2-positive early or locally advanced breast cancer[1][4][6].
- Brand names
- perjeta
- Other names
- fec-t + pertuzumab5-fluorouracil + epirubicin + cyclophosphamide + docetaxel + pertuzumab
02
Targets
TUBB (Tubulin (alpha and beta subunits))ERBB2 (Erb-b2 receptor tyrosine kinase 2)TS (Thymidylate synthase)TOP2A (DNA topoisomerase II)DNA
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