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Fecal microbiota transplant (Hunter Holmes McGuire VA Medical Center)

Development stage: Unknown
Lead developer: Hunter Holmes McGuire VA Medical Center
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal

Overview

This investigational fecal microbiota transplant (FMT) therapy is being developed by the Hunter Holmes McGuire VA Medical Center for the treatment of alcohol use disorder (AUD) in patients with cirrhosis. The therapy consists of processed fecal matter from healthy donors, enriched with beneficial bacteria from the Lachnospiraceae and Ruminococcaceae families. It aims to modulate the gut-brain axis by "resetting" the dysbiotic gut microbiome, thereby reducing alcohol cravings and consumption. Clinical studies led by Dr. Jasmohan Bajaj have demonstrated that a single FMT enema can increase microbial diversity, boost short-chain fatty acid-producing bacteria, and reduce AUD-related adverse events and cravings over a six-month period.

Other names: FMTFecal Microbial Transplant

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