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fecal microbiota transplant (Tel Aviv Sourasky Medical Center)
- Development stage
- Preclinical
- Lead developer
- Tel Aviv Sourasky Medical Center
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Fecal microbiota transplant is an investigational biologic therapy being evaluated by Tel-Aviv Sourasky Medical Center for the treatment of alopecia areata, an autoimmune disease that causes hair loss. [3, 7, 8] It is administered in capsule form and contains fecal microbiota collected from healthy donors. [3] The therapy aims to modulate the patient's immune system by restoring a healthy gut microbiome, as alopecia areata is understood to be driven by T-lymphocyte cells releasing pro-inflammatory cytokines around hair follicles. [2, 3] A randomized, triple-blind, placebo-controlled clinical trial (NCT04833179) sponsored by the medical center is designed to assess whether this intervention can influence disease severity and promote hair growth. [3]
- Other names
- fecal microbiota-Tel-Aviv Sourasky Medical Center-alopecia areataFMTfecal material transfer therapyMicrobiota Transplant TherapyMTT
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