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fecal microbiota transplant (University Health Network)
- Development stage
- Unknown
- Lead developer
- University Health Network
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
Fecal microbiota transplant (FMT) is an investigational biologic and microbiome-based therapy. The specific intervention led by Dr. Johane P. Allard at the University Health Network involved a Phase 2 randomized controlled trial using FMT from healthy lean donors to treat individuals with morbid obesity and insulin resistance. [2, 3] The therapy consists of a single dose of fecal filtrate administered via colonoscopy. [1, 5] Its proposed mechanism is to modulate the recipient's gut microbiome by introducing the complete microbial community from a lean donor, thereby altering gut bacterial composition and metabolic activity to improve insulin resistance and promote weight loss. [1, 5]
- Other names
- FMTfecal transferfaecal microbial transplantstool transplantstool transplantation
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