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fecal microbiota transplant (University of Wisconsin-Madison)
- Development stage
- Discontinued
- Lead developer
- University of Wisconsin–Madison
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Cell Therapies, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
Fecal microbiota transplant (FMT) is an investigational biologic therapy being studied by the University of Wisconsin, Madison, for the treatment of Alzheimer's disease in a Phase 1 clinical trial (NCT03998423). [3, 4] The intervention consists of oral capsules containing processed fecal matter from healthy donors. The primary biological target is the gut microbiome. The proposed mechanism of action involves modifying the composition of the gut microbiota to positively influence the microbiota-gut-brain axis. [3, 4] This modulation is hypothesized to reduce neuroinflammation, decrease the deposition of amyloid-β protein, and regulate tau hyperphosphorylation, thereby treating the cognitive deficits and underlying pathological features of Alzheimer's disease. [7, 8, 11]
- Other names
- FMTFecal Microbiota TransplantOral Fecal Microbiota Transplant
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