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Fecal Microbiota Transplantation (Chinese Academy of Medical Sciences)

Development stage: Unknown
Lead developer: Chinese Academy of Medical Sciences
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Fecal Microbiota Transplantation (FMT) is an investigational microbial therapy being evaluated by the Chinese Academy of Medical Sciences, Fuwai Hospital, for its potential to mitigate aging and frailty. Administered as oral capsules containing processed and screened donor stool, this therapy aims to restore a healthy and diverse gut microbiome in elderly individuals (aged 70-85). The underlying hypothesis is that age-related gut dysbiosis contributes to systemic inflammation and metabolic decline; by replenishing beneficial microbes, FMT may improve cognitive function, cardiovascular health, and physical performance. The intervention is currently being studied in the randomized, placebo-controlled STEP-aging pilot trial to assess its impact on clinical frailty phenotypes and various biomarkers of aging.

Other names: FMT capsulesOral Fecal Microbiota Transplantation

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