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fecal microbiota transplantation (Odense University Hospital)

Development stage: Discontinued
Lead developer: Odense Universitetshospital
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Rectal, Oral

Overview

Fecal microbiota transplantation (FMT) is an investigational microbiome therapy that was studied by Odense University Hospital for the treatment of psoriatic arthritis. The therapeutic approach involves transferring minimally processed fecal matter from a healthy, screened donor into the recipient's gastrointestinal tract to restore a healthy gut microbial community. The presumed mechanism of action is the modulation of the host's immune system via the restored gut microbiota, which is hypothesized to reduce the systemic inflammation that drives psoriatic arthritis. A Phase 2, double-blind, randomized, placebo-controlled trial (the FLORA trial, NCT03058900) evaluated a single gastroscopic-guided FMT administration into the duodenum as an add-on to methotrexate in patients with active peripheral psoriatic arthritis. [12, 17] While the procedure was found to be safe, it did not demonstrate efficacy over the placebo and was associated with a higher rate of treatment failure. [12, 16, 22]

Other names: fecal microbiota transplantFMTfecal bacteriotherapy

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