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fecal microbiota transplantation (Peking University People's Hospital)
- Development stage
- Preclinical
- Lead developer
- Peking University
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
An investigational fecal microbiota transplantation (FMT) therapy developed by Peking University People's Hospital for the treatment of severe low anterior resection syndrome (LARS). [2, 3] This biologic, microbiome-based therapeutic involves transplanting live bacterial communities from the feces of healthy donors into patients who have developed severe bowel dysfunction following rectal cancer surgery. [2, 4] The primary goal is to restore the balance and diversity of the gut microbiota to improve bowel function, including symptoms like urgency, frequency, and incontinence. [3] The therapy is being evaluated in a randomized, double-blind, single-center clinical trial comparing its effectiveness against a probiotic formula in 40 patients. [2]
- Other names
- FMT-LARS
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