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fecal microbiota transplantation (Sheba Medical Center, 4d72ab)
- Development stage
- Unknown
- Lead developer
- Sheba Medical Center
- Modality
- Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral, Rectal
01
Overview
Fecal microbiota transplantation (FMT) from Sheba Medical Center is an investigational microbial therapy being evaluated for the treatment of metastatic melanoma, particularly in patients who have failed anti-PD-1 therapy. The procedure involves the transfer of gut microbiota from donor patients who achieved a durable complete response to immunotherapy into refractory patients. The rationale is to modulate the recipient's gut microbiome to overcome resistance to immune checkpoint inhibitors like nivolumab and ipilimumab. In clinical studies, the FMT is administered via a single colonoscopy followed by oral maintenance capsules. It is often studied as part of a combination regimen that may include checkpoint inhibitors or tumor-infiltrating lymphocyte (TIL) therapy.
- Other names
- FMTFecal Microbiota TransplantationFMT Protocol
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