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Fecal microbiota transplantation (Shengjing Hospital of China Medical University)
- Development stage
- Unknown
- Lead developer
- Shengjing Hospital
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
Fecal microbiota transplantation (FMT) is a microbial therapy being developed by Shengjing Hospital for the treatment of functional constipation, particularly in children with fecal impaction. The therapy utilizes fecal supernatant derived from healthy donor stool, which is administered via retrograde colonic enema. The mechanism of action involves the restoration of a diverse and healthy intestinal microbiota, which helps to inhibit pathogenic bacterial growth, regulate the intestinal environment, and improve colonic motility. This approach aims to provide a more lasting solution than traditional laxatives by addressing the underlying microbial imbalance associated with chronic constipation.
- Other names
- FMTFecal supernatantRetrograde colonic enema with FMT
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