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fecal microbiota transplantation (St Vincent's Hospital Melbourne)
- Development stage
- Unknown
- Lead developer
- St Vincent's Hospital Melbourne
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal, Colonoscopy
01
Overview
Fecal microbiota transplantation (FMT) as developed and studied at St Vincent's Hospital Melbourne is an investigational microbial therapy for active Crohn's disease. The protocol involves a 'clearing' phase using a two-week course of oral antibiotics (typically metronidazole and ciprofloxacin) and dietary modifications to prepare the gut environment. This is followed by the administration of a diverse consortium of live bacteria from healthy donor stool, initially delivered via colonoscopy and subsequently through weekly rectal enemas for a maintenance period. The therapeutic rationale is to correct the intestinal dysbiosis characteristic of Crohn's disease, thereby inducing clinical and endoscopic remission by restoring a homeostatic microbial-immune interface and displacing pro-inflammatory pathogenic bacteria.
- Other names
- FMTfecal microbiota transplantstool transplant
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