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fecal microbiota transplantation (UANL)
- Development stage
- Unknown
- Lead developer
- Universidad Autónoma de Nuevo León
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal
01
Overview
Fecal microbiota transplantation (FMT) is a microbial therapy involving the transfer of stool from a healthy donor into the gastrointestinal tract of a recipient. This specific FMT protocol, developed by the Universidad Autonoma de Nuevo Leon (UANL), utilizes a Fecal Donor-Unrelated Donor Mix (FURM). The primary mechanism of action is the restoration of a diverse and functional gut microbiome, which provides colonization resistance against *Clostridium difficile*. By reintroducing a complex community of beneficial bacteria, FMT outcompetes *C. difficile* for nutrients and niches, and restores bile acid metabolism to inhibit the pathogen's germination and growth. It is primarily investigated for the treatment of initial and recurrent *Clostridium difficile* infections.
- Other names
- FMTfecal microbiota transplantFURM
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