felodipine + lisinopril

Felodipine + lisinopril is a combination of two antihypertensive agents used to treat high blood pressure. Felodipine is a long-acting dihydropyridine calcium channel blocker that works by inhibiting the influx of calcium ions through voltage-gated L-type calcium channels in vascular smooth muscle, leading to vasodilation and reduced blood pressure[3][6][8]. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that prevents the conversion of angiotensin I to angiotensin II, resulting in vasodilation and decreased aldosterone secretion, which also lowers blood pressure[5]. This combination targets different mechanisms within the cardiovascular system for additive antihypertensive effects.