Drug intelligence / Profile preview

fenofibric acid + atorvastatin + ezetimibe

Development stage
Phase 3
Lead developer
Abbott
Modality
Small Molecules
Administration
Oral
01

Overview

This drug is a combination of three lipid-lowering agents: **atorvastatin** (an HMG-CoA reductase inhibitor or statin), **ezetimibe** (a cholesterol absorption inhibitor), and **fenofibric acid** (the active metabolite of fenofibrate, a fibric acid derivative). The combination acts via complementary mechanisms to manage hypercholesterolemia and hypertriglyceridemia by reducing LDL cholesterol, decreasing cholesterol absorption in the intestine, and lowering triglyceride levels, while modestly increasing HDL cholesterol. It is primarily indicated for adults (and sometimes children over 10 years) with high cholesterol, severe hypertriglyceridemia, or homozygous familial hypercholesterolemia[1][3].

Other names
atorvastatin + ezetimibe + fenofibric acidatorvastatin + ezetimibe + fenofibrate
02

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)NPC1L1 (Niemann-pick C1-Like 1 transporter)PPARA (Peroxisome proliferator-activated receptor alpha)

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