Drug intelligence / Profile preview

fentanyl + lidocaine + bupivacaine + hyaluronidase

Development stage
Unknown
Lead developer
Cairo University
Modality
Recombinant Proteins and Enzymes, Small Molecules
Administration
Ophthalmic
01

Overview

This drug is a multi-component local anesthetic mixture used for peribulbar block in ophthalmic surgeries, specifically anterior segment procedures. It combines two amide-type local anesthetics, **lidocaine** (fast-onset) and **bupivacaine** (long-acting), with **hyaluronidase**, an enzyme that acts as a spreading agent to enhance the dispersion of the anesthetics through the orbital tissues. **Fentanyl**, a potent synthetic opioid, is added as an adjuvant to enhance the quality of the block, provide supplemental analgesia, and potentially prolong the duration of postoperative pain relief. The mixture is typically administered via peribulbar injection to achieve akinesia and anesthesia of the eye.

Other names
fentanyl + lidocaine + bupivacaine + hyaluronidase mixturefentanyl adjuvant peribulbar block
02

Targets

MOR (Mu opioid receptor)NaV (Voltage-gated sodium channels)

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