fentanyl + midazolam (84bf09)

Fentanyl + midazolam is a combination therapy consisting of a potent synthetic opioid analgesic and a short-acting benzodiazepine. Fentanyl acts as a mu-opioid receptor agonist, providing rapid and effective analgesia, while midazolam serves as a positive allosteric modulator of the GABA-A receptor, inducing sedation and anxiolysis. This specific combination is being evaluated by the **University of Texas at Austin** for intranasal administration in pediatric patients. The primary goal of this formulation is to provide effective pain relief and reduce anxiety during minor surgical procedures, such as the repair of facial lacerations, offering a non-invasive alternative to intravenous sedation in the emergency department setting.

Other names

intranasal fentanyl and midazolam combinationintranasal fentanyl spray and intranasal midazolam spray