fentanyl + propofol + atracurium

A combination of **fentanyl**, **propofol**, and **atracurium** is used in clinical anesthesia to achieve deep sedation, analgesia, and muscle relaxation, particularly for procedures such as intubation or surgery. - **Fentanyl** is a potent synthetic opioid analgesic, acting primarily as a mu-opioid receptor agonist, providing strong analgesic and sedative effects[1][2][6]. - **Propofol** is a short-acting intravenous sedative-hypnotic used for the induction and maintenance of anesthesia, with its primary effect as a positive allosteric modulator of the GABA-A receptor, resulting in CNS depression and hypnosis[5]. - **Atracurium** is a non-depolarizing neuromuscular blocking agent that causes skeletal muscle paralysis by competitively inhibiting acetylcholine at the neuromuscular junction[4]. This three-drug combination is commonly used for the induction and maintenance of anesthesia, especially when endotracheal intubation and mechanical ventilation are required. Each drug is titrated to effect, and their combination allows for rapid, controlled anesthesia and muscle relaxation, with fentanyl reducing noxious responses and propofol providing rapid loss of consciousness[2][8], while atracurium ensures muscle relaxation for intubation or surgical access[4].

Other names

fentanyl, propofol, atracurium