fentanyl + propofol + etomidate

**fentanyl + propofol + etomidate** is a pharmaceutical combination used for *rapid induction of anesthesia or procedural deep sedation*, particularly during intubation and other short, painful procedures. - **Fentanyl** is a fast-acting synthetic opioid analgesic that acts primarily via mu-opioid receptor agonism, providing potent analgesia and some sedation. - **Propofol** is a sedative-hypnotic agent and anesthetic that acts predominantly as a positive allosteric modulator of the GABA-A receptor; it produces rapid-onset sedation and hypnosis but no analgesia. - **Etomidate** is a nonbarbiturate sedative-hypnotic acting via GABA-A receptor modulation, used for induction of anesthesia with minimal cardiovascular effects but no analgesia. Combining these agents aims to leverage fentanyl's analgesia with the sedative properties of propofol and etomidate, allowing rapid and reliable induction of anesthesia and deep sedation while minimizing individual drug doses and potentially adverse effects[2][4][5]. Typical use includes intravenous administration in critical care and emergency situations, such as rapid sequence intubation or short procedural sedation.

Other names

fentanyl and propofol and etomidate combination