Drug intelligence / Profile preview

ferula communis extract + ferutinin

Development stage
Unknown
Lead developer
University of Magna Graecia
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ferula communis extract + ferutinin is a natural phytoestrogen-based botanical supplement derived from the non-toxic chemotype of *Ferula communis L.* (giant fennel). The extract is standardized to contain 20% ferutinin, a sesquiterpene ester that acts as a potent agonist of estrogen receptors (ERα and ERβ). Developed by researchers at the Magna Graecia University of Catanzaro (IRC-FSH), this nutraceutical is primarily investigated for the relief of postmenopausal symptoms and dysfunctions, including hot flashes, sexual behavior, and metabolic parameters like BMI. Clinical research published in 2024 demonstrated its efficacy in improving quality of life and reducing oxidative stress in postmenopausal women over a 90-day treatment period. Beyond menopausal relief, it has shown potential for the prevention of osteoporosis and as an antineoplastic agent due to its antiproliferative properties.

Other names
giant fennel extractferutinin-standardized Ferula communis extract
02

Targets

GPER1 (G protein-coupled estrogen receptor 1)ESR1 (ERα)ESR2 (ERβ)

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