fexofenadine + phenylephrine

Fexofenadine + phenylephrine is an oral pharmaceutical combination of two small molecule drugs—**fexofenadine**, a selective antihistamine (histamine H1 receptor antagonist), and **phenylephrine**, a sympathomimetic decongestant. Fexofenadine works by blocking histamine H1 receptors on effector cells in blood vessels and respiratory tract, thereby inhibiting the actions of endogenous histamine responsible for allergy symptoms[3]. Phenylephrine exerts its effect mainly through stimulation of alpha-adrenergic receptors, leading to vasoconstriction of blood vessels in nasal mucosa, which reduces swelling and congestion[2]. The combination is primarily indicated for relief of allergic symptoms such as sneezing, runny nose, and nasal congestion caused by allergic rhinitis or the common cold[2].