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FGLM-NH2 + SSSR
- Development stage
- Unknown
- Lead developer
- Yamaguchi University Graduate School of Medicine
- Modality
- Peptides
- Administration
- Ophthalmic
01
Overview
FGLM-NH2 + SSSR is an investigational ophthalmic solution composed of two synthetic tetrapeptides designed to treat persistent corneal epithelial defects (PCEDs), particularly those associated with neurotrophic keratopathy. FGLM-NH2 (Phe-Gly-Leu-Met-NH2) is a C-terminal analog of the neuropeptide substance P, while SSSR (Ser-Ser-Ser-Arg) is derived from the C-domain of insulin-like growth factor-1 (IGF-1). These peptides act synergistically to stimulate corneal epithelial cell migration and wound healing by activating the neurokinin-1 (NK-1) and IGF-1 receptor pathways, respectively. The combination has been primarily studied in clinical trials at Yamaguchi University in Japan as a treatment for intractable corneal disorders resistant to conventional therapies.
- Other names
- FGLM-NH2+SSSR eye dropsPhe-Gly-Leu-Met-NH2 + Ser-Ser-Ser-Arg
02
Targets
IGF-1R (Insulin-like growth factor 1 receptor)TACR1 (Neurokinin‑1 Receptor)
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