Drug intelligence / Profile preview

fimasartan + indapamide

Development stage
Phase 1
Lead developer
Boryung
Modality
Small Molecules
Administration
Oral
01

Overview

Fimasartan + indapamide is a fixed-dose combination of two antihypertensive agents used to treat high blood pressure (hypertension). Fimasartan is an angiotensin II receptor antagonist (ARB) that selectively blocks the type 1 angiotensin II receptor, leading to vasodilation, reduced aldosterone secretion, and decreased blood volume. This results in lower blood pressure and protective effects against cardiovascular events such as stroke and heart failure[2][6]. Indapamide is a thiazide-like diuretic that promotes sodium and water excretion by inhibiting sodium reabsorption in the distal tubules of the kidney, thereby reducing fluid retention and lowering blood pressure[1][3]. The combination targets different mechanisms involved in hypertension for additive or synergistic antihypertensive effects.

Brand names
Kanarb
Other names
BR1015 combination therapyBR-1015 combination therapyBR 1015 combination therapy
02

Targets

SLC12A3 (Thiazide-sensitive sodium-chloride cotransporter)AGTR1 (Angiotensin II Type-1 receptor)KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)

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