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Flexical is a multi-ingredient dietary supplement developed by Eldon Nutrition (under Eldon Healthcare) specifically formulated to support bone mineral density and skeletal health. The product utilizes a synergistic 4-in-1 combination of 600 mg elemental calcium (derived from eggshells), 800 IU of Vitamin D3 (cholecalciferol), 60 mcg of Vitamin K2 (as menaquinone-7), and 150 mg of magnesium. Its mechanism of action involves Vitamin D3-mediated enhancement of intestinal calcium absorption via the Vitamin D receptor (VDR), and Vitamin K2-dependent activation of Vitamin K-dependent gamma-carboxylase (GGCX), which is essential for the carboxylation of osteocalcin to facilitate calcium deposition into the bone matrix. Magnesium further contributes to the structural integrity of the bone and regulates calcium transport, while the calcium sensing receptor (CaSR) responds to systemic calcium levels to maintain homeostasis. Flexical is indicated for the maintenance of bone health in populations such as postmenopausal women, the elderly, and individuals with osteoporosis or lactose intolerance.
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