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Drug intelligence / Profile preview
floxuridine + gemcitabine + cisplatin
- Development stage
- Phase 2
- Lead developer
- Roche
- Modality
- Small Molecules
- Administration
- Intravenous, Hepatic Arterial Infusion
01
Overview
A combination chemotherapy regimen consisting of hepatic arterial infusion (HAI) of floxuridine (FUDR) with systemic administration of gemcitabine and cisplatin. This triplet therapy has been studied for the treatment of unresectable intrahepatic or hilar cholangiocarcinoma. The regimen works through multiple mechanisms to disrupt DNA synthesis and cell division in cancer cells.
- Other names
- FUDR + gemcitabine + cisplatingemcitabine/cisplatin plus HAI-FUDR
02
Targets
DNARNR (Ribonucleotide reductase)TS (Thymidylate synthase)
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