fluconazole + azithromycin + secnidazole

fluconazole + azithromycin + secnidazole is a fixed-dose combination (FDC) anti-infective therapy developed by Chem Med Pharmaceuticals for the treatment of mixed vaginal infections. This 'combikit' approach is designed for the syndromic management of vaginal discharge, addressing fungal, bacterial, and protozoal pathogens simultaneously. Fluconazole, a triazole antifungal, inhibits the enzyme lanosterol 14-alpha demethylase, disrupting fungal cell membrane synthesis. Azithromycin is a macrolide antibiotic that inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit. Secnidazole is a nitroimidazole derivative that enters the cell and is reduced to intermediates that cause DNA strand breakage, effectively treating anaerobic bacteria and protozoa like Trichomonas vaginalis. The combination is typically administered as a single-day oral regimen to ensure high patient compliance.

Brand names

Trizolac

Other names

Fluconazole, Azithromycin & Secnidazole TabletsFAS KitFluconazole 150mg / Azithromycin 1gm / Secnidazole 1gm combinationFluconazole, Azithromycin, Secnidazole