Fluoride + arginine

Fluoride + arginine is a combination used primarily in oral hygiene products for the prevention and management of dental caries. Fluoride acts as an anticaries agent by promoting tooth remineralization and inhibiting bacterial activity through glycolytic enzyme inhibition and cytoplasmic acidification. Arginine, an amino acid, serves as a substrate for alkali generation via the microbial arginine deiminase system, countering acid accumulation in dental biofilms. The combination has demonstrated synergistic effects, with clinical studies showing greater efficacy in reducing caries compared to fluoride alone. This synergy is attributed to both enhanced remineralization and modulation of the oral microbiota toward less pathogenic profiles[1][2].