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fluoride varnish + strontium-doped bioactive glass
- Development stage
- Unknown
- Lead developer
- The University of Hong Kong
- Modality
- Small Molecules, Hydrogel Systems → Drug Delivery Systems, Nanoparticles → Drug Delivery Systems, Device-based Delivery → Drug Delivery Systems
- Administration
- Topical
01
Overview
SBGC-fortified fluoride varnish is an investigational dental combination product developed by The University of Hong Kong for the prevention of root caries in older adults. The formulation consists of a 5% sodium fluoride varnish (Duraphat) supplemented with 7.5% strontium-doped bioactive glass (SBGC). The mechanism of action involves the synergistic release of fluoride, strontium, and calcium ions, which promote the remineralization of the tooth root surface. This process leads to the formation of strontium-substituted-hydroxyapatite and strontium-substituted-fluorohydroxyapatite, which exhibit enhanced bioactivity and reduced acid solubility compared to natural tooth mineral. It is currently being evaluated in a 36-month randomized double-blind controlled clinical trial.
- Other names
- SBGC Fluoride VarnishFluoride varnish with SBGCSBGC-fortified fluoride varnish
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