fluorouracil + gemcitabine + oxaliplatin

This is a combination chemotherapy regimen consisting of three cytotoxic agents—fluorouracil, gemcitabine, and oxaliplatin. Each drug has a distinct mechanism of action targeting cancer cell proliferation: - **Fluorouracil (5-FU)** is an antimetabolite and pyrimidine analog that inhibits thymidylate synthase, disrupting DNA synthesis and function[6]. - **Gemcitabine** is a nucleoside analog that incorporates into DNA during replication, leading to chain termination and apoptosis; it also inhibits ribonucleotide reductase[5]. - **Oxaliplatin** is a platinum-based compound that forms DNA crosslinks, inhibiting DNA replication and transcription. This combination aims to maximize anti-tumor efficacy by attacking cancer cells through multiple pathways. While not as widely established as regimens like FOLFIRINOX or GEMCITABINE-OXALIPLATIN for pancreatic cancer[1][7], combinations of these agents are under investigation in clinical trials for various solid tumors.