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fluorouracil + leucovorin + mitoxantrone + paclitaxel

Development stage: Unknown
Lead developer: Pfizer
Modality: Small Molecules
Administration: Intravenous

Overview

A combination chemotherapy regimen consisting of fluorouracil, leucovorin, mitoxantrone, and paclitaxel. This regimen was developed by adding paclitaxel to a previously established combination of mitoxantrone, fluorouracil, and high-dose leucovorin (NFL). It is primarily used in the treatment of metastatic breast cancer as first-line or second-line therapy.

Targets

TS (Thymidylate synthase)SLC46A1 (Proton-coupled folate transporter)TOP2A (DNA topoisomerase II)DNAMicrotubule

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