Fluorouridine (Non-specific)

"Fluorouridine" is a non-specific term that can refer to at least two distinct nucleoside analogs: 5-Fluorouridine and 4'-Fluorouridine. 5-Fluorouridine (FUrd) is a pyrimidine nucleoside analog that has been investigated for its anticancer properties. It acts by targeting uridine phosphorylase and is also a metabolite of 5-fluorouracil. Its mechanism of action involves interfering with DNA and RNA synthesis, primarily by inhibiting thymidylate synthase and being incorporated into RNA, leading to cell death in rapidly dividing cancer cells. 4'-Fluorouridine (4'-FlU, EIDD-2749) is a ribonucleoside analog developed as an oral antiviral agent. It demonstrates efficacy against a broad spectrum of RNA viruses, including SARS-CoV-2, Respiratory Syncytial Virus (RSV), avian influenza, and various hemorrhagic fever viruses (such as Nipah, Crimean-Congo, orthohantaviruses, and arenaviruses). Its antiviral mechanism involves inhibiting RNA-dependent RNA polymerase (RdRp), leading to transcriptional stalling and preventing viral replication.

Other names

5-Fluorouracil 1-beta-D-ribofuranoside5-Fur5-Fluoro-uridine