Drug intelligence / Profile preview

fluoxetine + citalopram + sertraline + paroxetine + escitalopram

Development stage
Unknown
Lead developer
Eli Lilly
Modality
Small Molecules
Administration
Oral
01

Overview

This is a combination of five selective serotonin reuptake inhibitors (SSRIs): fluoxetine, citalopram, sertraline, paroxetine, and escitalopram. Each of these drugs individually acts as an SSRI by inhibiting the reuptake of serotonin in the brain, thereby increasing its availability in the synaptic cleft and enhancing serotonergic neurotransmission. SSRIs are primarily used to treat major depressive disorder and various anxiety disorders. Combining multiple SSRIs is not standard clinical practice due to significant risks such as serotonin syndrome—a potentially life-threatening condition caused by excessive serotonergic activity—as well as increased risk for side effects including gastrointestinal upset, sexual dysfunction, sleep disturbances, abnormal heart rhythms (notably with citalopram), and drug interactions[1][2][3][4][5][6][7]. This combination does not correspond to any approved or recognized pharmaceutical product.

02

Targets

SERT allosteric site (Serotonin transporter allosteric site)

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