fluoxetine + clonazepam

Flux-C is a fixed-dose combination medication primarily marketed in India, consisting of the selective serotonin reuptake inhibitor (SSRI) fluoxetine and the benzodiazepine clonazepam. Fluoxetine exerts its antidepressant and anxiolytic effects by inhibiting the serotonin transporter (SERT), thereby increasing synaptic serotonin levels. Clonazepam acts as a potent positive allosteric modulator at the GABA-A receptor complex, enhancing inhibitory neurotransmission to provide rapid relief from acute anxiety, agitation, and insomnia. This combination is typically prescribed for patients suffering from major depressive disorder with comorbid anxiety or panic disorder, particularly during the initial weeks of treatment when SSRIs may paradoxically increase anxiety before their full therapeutic effect is realized.

Brand names

Flux-C

Other names

fluoxetine and clonazepam combination