fluoxetine + lithium

Fluoxetine + lithium is a combination therapy involving two well-established pharmaceutical agents—fluoxetine, a selective serotonin reuptake inhibitor (SSRI), and lithium, a mood stabilizer. This combination is primarily used in psychiatric practice for treatment-resistant depression and bipolar disorder when monotherapy is insufficient. Fluoxetine increases synaptic serotonin by inhibiting its reuptake at the presynaptic neuron, while lithium modulates neurotransmitter signaling through multiple mechanisms including inhibition of inositol monophosphatase and glycogen synthase kinase-3 (GSK-3). The combination may provide synergistic effects on neuroprotection, neurogenesis, and mood stabilization. However, co-administration increases the risk of adverse effects such as serotonin syndrome and long QT syndrome; careful monitoring of serum levels and clinical status is required[1][2][3][5][6].

Other names

fluoxetine and lithiumlithium and fluoxetineProzac plus lithium