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fluoxetine + metformin
- Development stage
- Preclinical
- Lead developer
- Eli Lilly
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Fluoxetine + metformin is a combination therapy that pairs fluoxetine, a selective serotonin reuptake inhibitor (SSRI) antidepressant, with metformin, an antidiabetic biguanide medication. This combination has been studied for multiple therapeutic applications including weight reduction in obesity, enhanced antidepressant efficacy, and potential neuroprotective effects. The combination appears to work synergistically, with metformin potentially counteracting the limited efficacy of fluoxetine when administered in stressful conditions by improving metabolic profiles. Studies have shown that this combination may be more effective than either drug alone in certain conditions.
- Other names
- metformin/fluoxetine
02
Targets
SERT (Sodium-dependent serotonin transporter)ND1 (Mitochondrial electron transport chain complex I)
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