flurbiprofen + famotidine

Flurbiprofen + famotidine is a fixed-dose combination of two small molecule drugs, formulated as a bi-layer or single tablet for oral administration. Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase (COX-1 and COX-2) enzymes, thereby reducing the synthesis of prostaglandins involved in pain, inflammation, and fever. Famotidine is a histamine H2 receptor antagonist that decreases gastric acid secretion by competitively inhibiting histamine at H2 receptors on gastric parietal cells. The rationale for combining these agents is to provide effective anti-inflammatory and analgesic therapy while reducing the risk of NSAID-induced gastrointestinal ulcers through acid suppression. This combination may be particularly useful in patients requiring long-term NSAID therapy who are at increased risk for gastrointestinal complications[1][3].