flurbiprofen + fluconazole

This is a combination of two small molecule drugs, flurbiprofen and fluconazole. Flurbiprofen is a non-steroidal anti-inflammatory drug (NSAID) that acts primarily as a cyclooxygenase (COX) inhibitor, used for the symptomatic treatment of rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and pain associated with inflammation. Fluconazole is an azole antifungal agent that inhibits fungal cytochrome P450 enzyme 14α-demethylase (CYP51), thereby blocking ergosterol synthesis and inhibiting fungal cell membrane formation; it is used to treat various systemic and superficial fungal infections including candidiasis. When combined, there are significant pharmacokinetic interactions due to fluconazole’s inhibition of CYP2C9—the main enzyme responsible for metabolizing flurbiprofen—leading to increased plasma concentrations and prolonged half-life of flurbiprofen. This combination may be considered investigational or experimental in the context of dual-action antifungal/anti-inflammatory therapy[1][2][3][4][5][6].