Drug intelligence / Profile preview

fluticasone + formoterol + salmeterol

Development stage
Discontinued
Lead developer
GSK
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Inhalation
01

Overview

This is a combination of three active pharmaceutical ingredients—fluticasone, formoterol, and salmeterol. Fluticasone is an inhaled corticosteroid that reduces inflammation in the airways. Formoterol and salmeterol are both long-acting beta-2 adrenergic agonists (LABAs) that act as bronchodilators by relaxing smooth muscle in the airways to improve airflow. This triple combination would theoretically provide anti-inflammatory effects from fluticasone and dual bronchodilation from two different LABAs (formoterol and salmeterol), though this specific triple combination does not appear to be an approved or marketed product based on available sources. Standard practice typically combines a corticosteroid with one LABA, not two.

02

Targets

GR (Glucocorticoid receptor)ADRB2 (β2)

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